ea0020p687 | Signal Transduction | ECE2009
Lucas Anna
, Colobran Roger
, Armengol Maria Pilar
, Ruiz Marta
, Martinez Eva
, Juan Manel
, Pujol-Borrell Ricardo
The mechanisms triggering autoimmunity in the Graves-Basedow disease (GBD) are unknown, although the evidence for a genetic predisposition is well established. The thyrotropin receptor (TSHR) is a good candidate gene.Objectives: To identify the main alleles/haplotypes of the TSHR gene, and to analyze the existence of TSHR susceptibility alleles to the GBD.Material and methods: To establish the main alleles of TSHR gene, 54 polymorp...